Growth failure and intestinal inflammation
نویسندگان
چکیده
منابع مشابه
Transforming growth factor and intestinal inflammation: the role of nutrition.
The intestinal mucosa possesses a complex epithelial barrier and a well-organized local immune system, which both efficiently protect this internal-external surface against potential microbial aggressions while guaranteeing tolerance towards harmless bacteria or antigens (oral tolerance). There is good experimental evidence that the intestinal microbiota is a main driver for the development of ...
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Severe short bowel syndrome (SBS) is a major cause of chronic (Type 3) intestinal failure (IF) where structural and functional changes contribute to malabsorption and risk of micronutrient deficiencies. Chronic IF may be reversible, depending on anatomy and intestinal adaptation, but most patients require long-term nutritional support, generally in the form of parenteral nutrition (PN). SBS man...
متن کاملProm1 Function in Development, Intestinal Inflammation, and Intestinal Tumorigenesis
Prom1/CD133 has been identified in colorectal, hepatocellular, and pancreatic cancer as a cancer stem cell marker and has been used as such to predict colon cancer recurrence in humans. Its potential molecular function as well as its role as a marker of intestinal regeneration is still not fully known. We evaluated the role of Prom1 in intestinal regeneration in inflammatory bowel disease (IBD)...
متن کاملCommentary: “Prom1 Function in Development, Intestinal Inflammation, and Intestinal Tumorigenesis”
A large body of publications mentioning prominin-1 (Prom1, CD133) is related to its use as a stem and cancer stem cell marker (1). Besides progenitor cells, its expression is widespread throughout terminally differentiated cells as those found in glandular organs (e.g., pancreas) and retina (2). Yet, the amino acid sequence of Prom1 didn’t reveal any motif or potential enzymatic activity that c...
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Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, contribute to significant morbidity and mortality globally. Despite an increase in incidence, IBD onset is still poorly understood. Mouse models of IBD recapitulate several aspects of human disease, but limited accessibility for live imaging and the lack of forward genetics highlight the need for new model ...
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ژورنال
عنوان ژورنال: QJM
سال: 2001
ISSN: 1460-2393
DOI: 10.1093/qjmed/94.3.121